Fig 1: Skin metastases from CD30-positive ALCL (a) before and (b) after CHOP-MTX: (c) Atypical mononuclear cell infiltrate extending into the subcutaneous fat (HE, x100); (d) Infiltrate composed of large cells with vesicular nuclei with prominent nucleoli as well as small lymphocyte-like cells (HE, x400); (e) Positivity for CD3; (f) Lymph node biopsy showing diffuse infiltrate of large malignant lymphoid cells with multinucleated giant cells (HE, x100).